There are a lot of single functional synthetic RNA control units; such as protein responsive or small RNA responsive units. Such units either turns on or turns off its original function upon in contact with their target. In this project, we plan to build a dual-functional unit, of which the target sensing ability of the unit it regulated by a secondary molecule. Such control unit is expected to be used to sense target molecules at a defined time or location.
nucleic acid design and synthesis; RNA structure prediction and modification; RNA-target binding measurement.
To learn the structure-function correlation of RNA; to understand and analyse the complex role of RNA; to improve project design base on observed results.