Development of low-cost rapid pathogen detection microsystem in COVID-19 Pandemic: Electronic Engineering Approach
Project Description

Due to the massive outbreak of Coronavirus-19 worldwide, rapid and accurate detection of pathogenic microorganisms has become a top priority. Compared to the current centralized detection mode, miniaturized detection platforms could enable real-time and on-spot testing of diseases, which could reduce the unnecessary pressure on medical system and avoid the possible contamination of samples during shipment. Our research team wants to integrate the CMOS ion-sensitive field-effect transistors (ISFETs) with microfluidics to propose a rapid electrochemical detection system for COVID-19. The microfluidics will take part of DNA extraction from samples and the on-chip PCR while the ISFETs will be used to detect the pH change during the amplification process. Subsequently, the system can also be used to establish an IoT platform for more convenient and effective data management by integrating Bluetooth modules with the cloud for wireless data transfer.

Supervisor
LEE Yi-Kuen
Quota
4
Course type
UROP1000
UROP1100
UROP2100
UROP3100
UROP4100
Applicant's Roles

Successful candidates are expected to use Open-source Arduino MCU platform for the integration of ISFET (Ion-Sensitive Field-Effect Transistor) bio-sensor and the interface electronic circuit on the printed circuit board (PCB). Tasks to be done in this project:
• Arduino-based sensor system with the fabricated ISFETs
• Interface electronic circuit for ISFETs on the PCB and the wireless communication with the smartphone

Applicant's Learning Objectives

• Improve analytical skills when analysing electronic circuits
• Consolidate experience in PCB design
• Acquire hands-on practice on testing electronic components

Complexity of the project
Moderate