Many neurodegenerative diseases show abnormal mitochondrial morphology and biochemical dysfunction. It is unclear whether there is any abnormalcy of mitochondria caused by mutant Huntingtin protein in Huntington's disease. We are investigating whether there is any defect in mitochondria in our Huntington's disease mouse model.
Testing whether mutant Huntingtin proteins disrupt the functions of mitochondria in
Huntington's disease mouse model by measuring the size and number of mitochondria.
Learning how to solve the important biological questions.