Organic molecules have been used as drugs for treatments of various diseases over the past centuries, as building blocks for polymer-based materials including plastics, dyes, coatings, etc and as an important source of inspiration for discovery of new chemistry. Preparation of organic molecules, a very interesting but challenging process, very often requires employments of toxic and reactive reagents that imcrease the cost and time and produce hazardous substances. Herein, this project will be focused on new synthetic method development, which is based on Green Chemistry: utilization of a set of principles that reduce or eliminate the use or generation of hazardous chemicals. Specifically, a new synthetic protocol with environmentally friendly reagents is identified, optimized, and finally demonstrated to make medicinally valuable organic molecules such as indole-containing compounds/natural products. In addition, the project provides trainings of undergraduate students to be able to carry out multiple steps of organic reactions (less than 10) and to interpret spectroscopic data at intermediate/advanced level of analytical skills (NMR, TLC, HPLC, column chromatography, and IR). Students enrolled this project are required to take and pass the safety training courses (Chemical Safety I and II).
The applicant will be trained first by Postdoc or graduate students and then take the leading role in examining the substrate scope with consultation/assistance of postdoc/pg student instructor.
Organic synthesis and structural elucidation of organic compounds with NMR and other analytical skills.