Mechanisms of influenza A virus replication and implication to new drug discoveries
Project Description

The project will be focusing on using a combination of experimental and computational approaches to understand the mechanisms of replication and the origins of mutations in Influenza A virus polymerase. The research will provide the molecular basis for transcription error, and provide significant insight on the rational design of antiviral drugs targeting the polymerase.

Supervisor
HUANG Xuhui
Co-Supervisor
CHEUNG Pak Hang Peter
Quota
2
Course type
UROP1000
UROP1100
UROP2100
UROP3100
UROP4100
Applicant's Roles

To help and acquire new experimental skills such as deep sequencing (next generation), PCR, bacterial cloning, gel electrophoresis, nucleic acid extraction, protein purification, in vitro transcription assays.

To help on lab maintenance and record keeping

Applicant's Learning Objectives

To develop new experimental skills and to design and perform experiments under supervision

To execute a project with great comprehensive and writing skills

To learn the principles of molecular biology and genome and protein engineering

Complexity of the project
Challenging