The project will be focusing on using a combination of experimental and computational approaches to understand the mechanisms of replication and the origins of mutations in Influenza A virus polymerase. The research will provide the molecular basis for transcription error, and provide significant insight on the rational design of antiviral drugs targeting the polymerase.
To help and acquire new experimental skills such as deep sequencing (next generation), PCR, bacterial cloning, gel electrophoresis, nucleic acid extraction, protein purification, in vitro transcription assays.
To help on lab maintenance and record keeping
To develop new experimental skills and to design and perform experiments under supervision
To execute a project with great comprehensive and writing skills
To learn the principles of molecular biology and genome and protein engineering