Mimicking membraneless organelles with synthetic materials
Project Description

Membraneless organelles are compartments in the cell that allow dynamic assembly of biomacromolecules to undergo important biochemical reactions. Liquid-liquid phase separation, which is the underlying physical phenomenon, is facilitated by the non-covalent assembly of intrinsically disordered proteins (IDP). This project is about designing and preparing materials to imitate IDP, followed by characterization of phase behaviour in different environments.

Supervisor
CHAU Ying
Co-Supervisor
CHAU Ying
Quota
1
Course type
UROP1000
Applicant's Roles

-Assist in the preparation of IDP-like materials
-Characterize the IDP-like materials
-Analyse the thermodynamics parameters related to phase separation

Applicant's Learning Objectives

-learn basics of polymer and peptide synthesis
-apply thermodynamics principles in understanding biomaterials behaviour

Complexity of the project
Challenging