A Minimal Dinoflagellate
Project Description

The dinoflagellates not only have genome sizes up to 80-100 times that of human beings (up to 250 vs 3 pg of haploid genome size), they are also devoid of detectable-nucleosomes and their chromosomes are apparently quasi-condensed throughout the cell cycle. Why do they have so much DNA is still a mystery; one hypothesis of non-coding domains beingâ

Supervisor
WONG Joseph Tin Yum
Quota
1
Course type
UROP1100
UROP2100
UROP3100
UROP4100
Applicant's Roles

To apply agent to induce DNA fragmentation and to isolate surivivng strains. Monitoring the resulting lineage in genome size with repeated treatment

Applicant's Learning Objectives

The project will involve molecular and cell biological techniques in the generation and monitoring of dinoflagellate lines. Depending on the progress, techniques in culturing other both heterotrophic and photosynthetic species may be involved.

Complexity of the project
Moderate