Delivering to the corneal stroma remains challenging because of the rapid clearance on the ocular surface and the barrier function of corneal epithelium. This project aims to examine the use of ultrasound and controlled release technology to overcome the problems. An important aspect of the project is to understand the mass transport and its relationship with the parameters of drug delivery technology, including ultrasound parameters and the drug release profile of the depot.
The student will construct a mathematical model to describe the corneal delivery into the stroma. He/she will need to work with members of the lab to obtain the necessary transport parameters (e.g. diffusion coefficients) for the model, and wil use computational tool to simulate various scenarios representing of the perturbation introduced by the delivery technology.
-Acquire basic concepts in drug delivery
-Model transport phenomena and apply to ocular drug delivery
-Learn techniques in measuring drug penetration/drug release and how to correlate data with transport parameters
-Communicate effectively results of mathematical model with experimentalists