Molecular mechanisms regulating secretion of sonic hedgehog
Project Description

Sonic hedgehog (Shh) is a signal protein that plays a very important role in a variety of developmental processes. Defects in Sonic hedgehog mediated signaling are associated with many human diseases. Although significant progresses have been achieved in understanding how Shh is recognized by the recipient cells and the down-stream signaling transduction pathway induced by Shh, how Shh is secreted out of the producing cells remain unclear. In this project, we aim to explore the molecular mechanisms regulating secretion of sonic hedgehog.

Supervisor
GUO Yusong
Quota
1
Course type
UROP1100
UROP2100
UROP3100
UROP4100
Applicant's Roles

The students will perform biochemistry and imaging experiments to identify key factors regulating Shh secretion.

Applicant's Learning Objectives

To learn classical biochemical and imaging approaches to explore scientific questions.

Complexity of the project
Moderate