Sonic hedgehog (Shh) is a signal protein that plays a very important role in a variety of developmental processes. Defects in Sonic hedgehog mediated signaling are associated with many human diseases. Although significant progresses have been achieved in understanding how Shh is recognized by the recipient cells and the down-stream signaling transduction pathway induced by Shh, how Shh is secreted out of the producing cells remain unclear. In this project, we aim to explore the molecular mechanisms regulating secretion of sonic hedgehog.
The students will perform biochemistry and imaging experiments to identify key factors regulating Shh secretion.
To learn classical biochemical and imaging approaches to explore scientific questions.