The failure of axon regeneration in the adult mammalian central nervous system (CNS) are attributed to two properties of the adult CNS, the inhibitory extrinsic environment and a diminished intrinsic regenerative capacity of mature CNS neurons. The project is to identify and study the novel genes involved in axon regeneration, particularly through intrinsic regulation.
UG students will work with senior graduate students and use cell biology and molecular biology approaches to study axon regeneration by using both in vitro and in vivo mouse models.
1. Learn to develop critical thinking skills. 2. Learn to design experiments, and interpret experimental results. 3. Learn to perform basic cellular and molecular techniques to study axon growth and regeneration.