Nanoparticles for delivering nucleic acids to the retina
Project Description

This project aims to understand the parameters (size, charge, surface ligands) of nanoparticles influencing their distribution after intravitreal injection. It explores the relative importance of different modes of transport (diffusion vs convection vs cell-mediated transport) when nanoparticles travel through retina.

Students need to take safety training required by the department before conducting experiments

Supervisor
CHAU Ying
Co-Supervisor
CHAU Ying
Quota
2
Course type
UROP1000
UROP1100
UROP2100
UROP3100
UROP4100
Applicant's Roles

Prepare and characterize nanoparticles
Assist in animal experiments (in vivo and ex vivo) to obtain nanoparticle distribution
Perform cell culture experiments to determine gene transfection/silencing efficiency
Fit experimental data with transport model

Applicant's Learning Objectives

Describe design criteria of nanoparticles for retinal delivery
Aquire techniques for preparationn and evaluation of nanomaterials
Analyze data on drug distribution

Complexity of the project
Challenging