This project is founded on the discovery of virus-mimicking nanostructures from the spontaneous co-assembly of designer peptides and nucleic acids in my laboratory. The goal is to modify the nanocarriers to increase their effectiveness for the delivery of nucleic acids to cells, in particular, to increase the efficiency of endosomal escape.
The student will assist in the chemical modification of the nanocarriers and their characterization, especially in the image analysis for understanding of intracellular trafficking. In the second part of the project, the student will explore the possibility of using the nanocarriers for the encapsulation and delivery of mRNA.
-Appreciate the application of nanotechnology in nucleic acid medicine
-Learn basic techniques in peptide synthesis, characterization of nanostructures, and imaging of intracellular events.
-Design experiments for the evaluation of delivery of nucleic acid medicines by nanocarriers