Study of Blood Cell Development using Zebrafish Model
Project Description

Blood cell formation is a sophisticated biological process which generates dozens of functionally divergent cells such as red blood cells, phagocytes, and lymphocytes. Dysregulation of this process is repeatedly seen in many kinds of diseases including cancer. Our laboratory is thus keen to understand the developmental mechanism that establishes the blood system and how its dysregulation incurs diseases. Toward this end, we are utilizing zebrafish, a tiny tropical fish whose blood system shares many similarities to humans, as a model organism to uncover the molecular basis underlying the formation of blood stem cells and tissue-resident macrophages.

Supervisor
WEN Zilong
Quota
2
Course type
UROP1000
UROP1100
UROP2100
UROP3100
UROP4100
Applicant's Roles

UG students (under proper supervision of postdoctoral fellows or senior Ph.D. students) will use genetic, cell biology and molecular biology approaches to study the formation of white blood cells using zebrafish as a model organism.

Applicant's Learning Objectives

1. Explore how to use genetic approach to tackle a biological question
2. Learn how to perform basic cellular and molecular techniques to study cell and organ development in model organisms

Complexity of the project
Moderate