Ultrasound-triggered drug/gene release from self-assembling carriers
Project Description

Artificial membraneless organelles (AMOs) have been constructed by the self-assembly of polymer-peptide, and are currently being explored as new carriers of drug and gene for cellular delivery. This projects aims to investigate the use of ultrasound to perturb non-covalent interactions and trigger the release of cargoes carried by AMOs.

Supervisor
CHAU Ying
Co-Supervisor
CHAU Ying
Quota
2
Course type
UROP1000
UROP1100
UROP2100
UROP3100
UROP4100
Applicant's Roles

-Investigate the effect of ultrasound on the morphology of AMOs
-Develop protocols to quantify the loading and release of drugs and genes from AMOs.
-Optimize the ultrasound parameters (frequency and duration) to release cargoes from AMOs

Applicant's Learning Objectives

-Appreciate the application of biomaterial for drug and gene delivery
-Understand the concept of stimuli-responsive release
-Learn basic techniques in polymer modification and characterization of micro- and nano- drug carriers
-Design experiments for the evaluation of drug and gene release

Complexity of the project
Challenging