Nanoparticles for delivering nucleic acids to the retina
Supervisor:
CHAU Ying
Co-Supervisor:
CHAU Ying
Quota:
2
Project Description:
This project aims to understand the parameters (size, charge, surface ligands) of nanoparticles influencing their distribution after intravitreal injection. It explores the relative importance of different modes of transport (diffusion vs convection vs cell-mediated transport) when nanoparticles travel through retina.
Students need to take safety training required by the department before conducting experiments
Course type:
UROP1000 UROP1100 UROP2100 UROP3100 UROP4100
Applicant's Roles:
Prepare and characterize nanoparticles
Assist in animal experiments (in vivo and ex vivo) to obtain nanoparticle distribution
Perform cell culture experiments to determine gene transfection/silencing efficiency
Fit experimental data with transport model
Applicant's Learning Objectives:
Describe design criteria of nanoparticles for retinal delivery
Aquire techniques for preparationn and evaluation of nanomaterials
Analyze data on drug distribution
