UROP Project Listing System
Project Title:
G protein-coupled receptors in cell signaling
Supervisor:WONG Yung Hou
Project Description:The superfamily of G protein-coupled receptors (GPCRs) constitute the largest cell-surface detectors for hormones, neurotransmitters, photons, and numerous other extracellular signals. In order to thoroughly understand how the GPCRs regulate cellular functions, specific combinations of receptors and G protein subunits will be expressed in mammalian cell lines, and their effects on downstream effectors assessed by measuring the activities of selected enzymes, kinases, and ion channels.
Course type: UROP1100 UROP2100 UROP3100 UROP4100 
Applicant's Roles:The applicant is expected to assist in generating research tools (e.g., GPCR and G protein mutants) and perform routine experiments. The applicant will work with an experienced researcher. A good understanding in cell biology is preferred. 
Applicant's Learning Objectives:The learning objectives for the project include, but not limited to, the following: 1. Standard laboratory skills (e.g., preparing reagents) 2. Basic recombinant DNA techniques (e.g., restriction digests) 3. Basic protein chemistry techniques (e.g., SDS-PAGE) 4. Planning and execution of experiments 5. Data analysis and presentation 6. Foundation in cell signaling 
Complexity of the project:Moderate 

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