Arduino-based Nano-bioimedance Sensor System for Detection of Cancer Cells
Cancer is one of the top killers in Hong Kong and the other world. Conventional cancer diagnostics using invasive biopsy and/or positron emission tomography in hospitals is expensive and time-consuming. Micro electrochemical biosensors are promising for point-of-care diagnosis of cancer, a leading cause of death worldwide. Cancer cells have different electrical properties, i.e. impedance, capacitance, etc., as compared to normal ones due to altered cell properties, i.e. different metabolism, distinct membrane permeability for Na/Ca/Mg ions, etc
This project is to design and fabricate a low-cost Arduino-based nanno-bioimpedance sensor system. The design and manufacturing of this prototype are challenging.
UROP1000 UROP1100 UROP2100 UROP3100 UROP4100
Each student will be responsible for one of the following design and manufacturing:
1. Design and fabricate nano-bioimpedance sensor chip,
2. Packaging of the nano-bioimepdance Sensor System,
3. Design and fabricate the interface electronic circuit for the nano-bioimepdance sensor chip,
4. Design a computer program on an Arduino microcontroller for the analysis of impedance spectra.
Applicant's Learning Objectives:
Understand basic principle of bioimpedance sensing
Develop an understanding of the electric and biological properties of cancer cells
Develop experimental skills to record and to analyze the impedance data from nano-bioimpeance sensor
Develop and practice communication and team skills.