Supersoft hydrogel for extended drug delivery on the eye surface
Our lab has developed super-soft and biocompatible hydrogel for topical instillation on the eye. This project will further characterize the rheological properties of the gel, and explores applications related to prolonged drug delivery with the potential for enhanced treatment effect in dry eye and corneal wound healing.
The student will carry out detailed rheological characterization of the material. He/she will participate in the design of hydrogel formulation appropriate for the extended release of drugs of interest. The student may also have opportunities to work with the current research team on animal studies for evaluating the effectiveness of the hydrogel formulation.
Applicant's Learning Objectives:
1) Understand the criteria of biomaterials for drug delivery, especially in ocular applications
2) Practice lab techniques for material preparation (both chemical modification and purification)
3) Characterize rheological properties of biomaterials
4) Measure drug release profiles using HPLC/ colorimetric assays